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discofeversn.
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Follica Developing Breakthrough Discovery to Treat Hair Loss, Wounds and Other Degenerative Skin Disorders
BOSTON, MA UNITED STATES 05/16/2007
BOSTON, May 16 /PRNewswire/ -- Technology licensed by Follica Inc. from
the University of Pennsylvania School of Medicine has been used to generate
completely new hair follicles for the first time in normal adult mammals.
The paper describing the experiment was published in the May 17th issue of
the scientific journal Nature.
(Photo: http://www.newscom.com/cgi-bin/prnh/20070516/NEW086-a)
(Logo: http://www.newscom.com/cgi-bin/prnh/20070516/NEW086LOGO-b)
By studying wound healing on a molecular level, Dr. George Cotsarelis
and colleagues discovered that the skin has the ability to revert to a more
primitive or "embryonic" state as stem cells migrate to the affected area,
thereby achieving a regenerative capacity not previously appreciated to
occur in adults.
The researchers were able to control the regenerative response,
including the extent of new hair follicle formation, by manipulating
genetic pathways during this "embryonic window" when new follicles formed.
The new hair follicles functioned normally, cycled through the normal
stages of hair growth and exhibited normal architecture, including a full
complement of stem cells. Cotsarelis and colleagues showed that the
induction of this primitive state triggered corresponding embryonic
molecular pathways distinct from those active in corresponding cells in
adult skin, opening up new treatment options not previously thought to have
therapeutic benefit in normal adult skin.
"The 'embryonic window' gives us the opportunity to develop disease
treatments that act in entirely novel ways," said Daphne Zohar, PureTech
Ventures founding managing partner and Follica CEO. "The clinical
translation of this technique involves straightforward, safe dermatological
procedures, and we are studying the impact of multiple drugs and drug-like
compounds on this regenerative response as we advance in preclinical
testing."
"This is an extremely exciting discovery and shows promise for
treatment of follicular disorders such as hair loss and unwanted excess
hair," noted Dr. Vera Price, co-founder of the National Alopecia Areata
Foundation, director of the University of California, San Francisco (UCSF)
Hair Research Center and a founding scientific advisory board member of
Follica Inc.
"The hair follicle is an elegant structure that plays many different
roles for human skin, aside from growing hair," said Dr. Rox Anderson,
Professor of Dermatology at Harvard Medical School, Director of the Wellman
Center for Photomedicine at Massachusetts General Hospital, and founding
chairman of Follica's scientific advisory board. "George Cotsarelis'
insights into the biology of hair follicles provide new strategies for
preventing and treating a variety of skin and hair disorders."
Follica exclusively licensed the technology from The University of
Pennsylvania School of Medicine where it is the basis of an ongoing
development program. The paper's lead author, Dr. Cotsarelis, is also a co-
founder and scientific advisory board member of Follica
About Follica
Follica Inc., a privately held medical device company, was co-founded
by PureTech Ventures and a group of world renowned experts in hair follicle
biology and medicine. In addition to hair loss, Follica has intellectual
property and development programs in various skin and follicle related
indications. Additional Follica contributors include Dr. Kurt Stenn
(Aderans Research, formerly of J & J, Yale) member of Follica's scientific
advisory board; Dr. Ron Cape (PureTech partner, founder Cetus, former board
member Neutrogena) Follica board member; and Dr. Steve Prouty (former J&J
skin biology) Follica director of research. http://www.follicabio.com
About PureTech Ventures
PureTech Ventures is a Boston-based venture firm specializing in
translating breakthrough research from top tier academic institutions into
therapies that will impact human health and quality of life. PureTech's
partners include entrepreneurs and leaders from the top echelon of pharma,
biotech, medtech and academia. http://www.puretechventures.com
http://www.prnewswire.com/cgi-bin/stories....04590099&EDATE=
http://business.bostonherald.com/businessN...001649&srvc=biz. -
chicco555.
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e cosa sarebbe questa sostanza????fa ricrescere i follicoli quindi i capelli????
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noel.
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http://www.almanacco.rm.cnr.it/base.asp?ID...ile=251_08_2007 . -
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Back to Story - Help
Study offers hope of remedy for baldness By Will Dunham
Wed May 16, 2:10 PM ET
Mice with deep skin wounds can grow new hair, scientists said on Wednesday in a finding that offers hope for a baldness remedy for humans.
The mice regenerated hair at the site of the wound via molecular processes similar to those used in embryonic development, according to the research, published in the journal Nature.
The findings show mammals possess greater regenerative abilities than commonly believed. While some amphibians can regenerate limbs and some reptiles can regenerate tails, regeneration in mammals is far more limited.
Dr. George Cotsarelis, a dermatology professor at the University of Pennsylvania School of Medicine in Philadelphia who led the study, said the findings dispel the dogma that hair loss is permanent in people and other mammals, and that once they are lost new hair follicles cannot grow.
Cotsarelis said the findings could pave the way for remedies for male-pattern baldness and other types of hair-loss. He said the idea would be to apply compounds to get epidermal cells to turn into hair follicles.
The regenerated follicles functioned normally, cycling through the various stages of hair growth, and the hair was indistinguishable from neighboring hair with a key exception -- it lacked pigmentation and was white.
The otherwise brown-haired mice had patches of white hair marking the site of the wound.
Cotsarelis said the white-hair issue may not materialize in any baldness remedy in people because the human pigmentation system differs from that in mice.
NEW HAIRS FORMED
The researchers made relatively large wounds on the backs of adult mice, and found that if a wound reached a certain size new hairs formed at its center, with the skin undergoing changes mimicking stages of embryonic hair-follicle development.
Dormant embryonic molecular pathways were activated, sending stem cells -- master cells able to transform into other cell types -- to the damaged skin.
The stem cells that gave rise to the regenerated follicles were not stem cells usually associated with hair-follicle development.
"They're actually coming from epidermal cells that don't normally make hair follicles. So they're somehow reprogrammed and told to make a follicle," Cotsarelis said.
The researchers also found a way to amplify the natural regeneration process, causing mice to grow twice as many new hairs by giving the skin a specific molecular signal.
Cotsarelis is involved with Follica Inc., a privately held start-up company that has licensed the patent on the process from the University of Pennsylvania. He said it probably would be more than five years before a treatment was possible.
Cotsarelis also envisioned treating wounds in a way that would leave skin with hair follicles, sweat glands and other normal attributes that would be functionally and cosmetically much better than a scar.
Dr. Cheng-Ming Chuong, a professor of pathology at the University of Southern California who was not involved in the study, said it proved the principle that hair can regenerate from adult skin, but cautioned that human skin differs from mouse skin.
"Repair and regeneration appear to be in competition," Chuong said by e-mail.
"Since fast-closing wounds help the survival of wild animals, repair often dominates regeneration. In the practice of medicine, physicians are trained to close wounds as soon as possible, thus leaving not enough time for regeneration to occur."
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noel.
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Translate... please...!!!
Non è ke tutti sappiano l'inglese...!!!
io in primis
Noel. -
felix212.
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Qualkuno di buona bontaaaa puo fare la traduzione? Lo oL dai...fai questo favore.. . -
|O_o|.
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So 20 centesimi a parola felix... prepara gli spicci... Ve lo traduco stasera se faccio in tempo, o domattina, ora non so ispirato... . -
pat2.
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niente di nuovo. niente di interessante a breve termine. e comunque molto preliminare.
dicono che la pelle ha proprieta' rigenerative. ed anche i follicoli capilliferi.
lo sapevamo!
bisogna pero' trovare le sostanze che mandino il segnale di rigenerazione.
sono piu' indietro di curis che almeno ne aveva trovata una che pero' non ha superato la fase di safety.
da ex ricercatore:
serve giusto per pubblicare un abstract e poi altri 30 uguali in ambiente universitario. -
|O_o|.
User deleted
Grazie pat, mi hai risparmiato anche la traduzione . -
noel.
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mah...!!!. -
pat2.
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grazie a Te, LOol.
di buono c'e' che e' una sorta di conferma al metodo di Intercitex.
Solo che ICX le staminali le estrae, le moltiplica e le reimpianta, Cotsarellis ha dimostrato che ferendo un topo e utilizzando certe proteine sulla ferita, il derma produce staminali che inducono la crescita di nuovi follicoli.
e' una tecnica che vedo bene su Antorway e Rik75.... -
noel.
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Direi di si... Facciamola sperimentare su Antorway
Noel. -
|O_o|.
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Sì, diciamo che questo metodo potrebbe essere il metodo di un futuro ulteriore a quello di ICX, perchè non estrae e duplica niente, ma fa ricrescere i capelli con cose che hai già in testa... ma lo ripeto, sti cazzi del metodo e di chi lo brevetta, a noi ci serve solo che funzioni! . -
noel.
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http://www.repubblica.it/2007/05/sezioni/s...vi-pillola.html
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default user.
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Anche questi sono un po' indietro.. Almeno altri 5 anni.. .
Follica |
